Katayama Y, Katsumata T, Muramatsu H, Usuda K, Obo R, Terashi A
Second Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Brain Res. 1997 Jul 4;761(2):300-5. doi: 10.1016/s0006-8993(97)00350-8.
The objective of this study was to determine the effect of ethyl eicosopentate (EPA-E) on local cerebral blood flow (1-CBF) and local glucose utilization (1-CGU) in specific regions of the brain in stroke-prone spontaneously hypertensive rats (SHRSP). EPA-E (100 mg/kg body weight) or saline was orally administered to 8-week-old SHRSP. L-CBF and 1-CGU in the EPA-E-treated, saline-treated, and 8-week-old control rats were measured autoradiographically using 14C-iodoantipyrine and 14C-deoxyglucose (Sakurada's and Sokoloff's methods). The 1-CBF of the saline-treated group decreased significantly with age in all areas measured. EPA-E treatment alleviated the age-dependent decrease in 1-CBF in all areas, especially those in the basal ganglia. The 1-CGU of the saline-treated group did not change with age, however EPA-E treatment increased 1-CGU in all areas measured, though the changes were not significant. EPA-E ameliorated the decrease in cerebral blood flow and improved glucose metabolism in SHRSP suffering from severe hypertension. These results suggest that EPA-E may be useful in the prevention of stroke.
本研究的目的是确定二十碳五烯酸乙酯（EPA-E）对易患中风的自发性高血压大鼠（SHRSP）脑特定区域局部脑血流量（1-CBF）和局部葡萄糖利用（1-CGU）的影响。将EPA-E（100毫克/千克体重）或生理盐水口服给予8周龄的SHRSP。使用14C-碘安替比林和14C-脱氧葡萄糖（Sakurada法和Sokoloff法）通过放射自显影法测量EPA-E处理组、生理盐水处理组和8周龄对照组大鼠的1-CBF和1-CGU。在所有测量区域，生理盐水处理组的1-CBF随年龄显著降低。EPA-E处理减轻了所有区域1-CBF随年龄的下降，尤其是基底神经节区域。生理盐水处理组的1-CGU不随年龄变化，然而EPA-E处理使所有测量区域的1-CGU增加，尽管变化不显著。EPA-E改善了重度高血压SHRSP的脑血流量下降并改善了葡萄糖代谢。这些结果表明EPA-E可能对预防中风有用。
