Husmann M J, Fuchs P, Truttmann A C, Laux-End R, Mullis P E, Peheim E, Bianchetti M G
Department of Pediatrics, Institute of Physiology, University of Bern, Switzerland.
Miner Electrolyte Metab. 1997;23(2):121-4.
It is unclear whether insulin-dependent diabetes mellitus is a state of magnesium depletion. This is a relevant question, since magnesium deficiency has been implicated in the pathogenesis of diseases that develop to an increased extent into diabetes mellitus. Total plasma magnesium was not statistically different in 76 pediatric patients with insulin-dependent diabetes mellitus (0.77 [0.73-0.81] mmol/l; median and interquartile range), 59 healthy adults (0.80 [0.77-0.83] mmol/l) and 19 healthy children (0.80 [0.78-0.83] mmol/l). In contrast, plasma ionized magnesium, the most interesting form with respect to physiological and biological properties, was significantly lower in diabetic patients (0.50 [0.48-0.53] mmol/l) when compared with healthy adults (0.53 [0.50-0.56] mmol/l; p < 0.01) and healthy children (0.54 [0.51-0.56] mmol/l; p < 0.02). Our report confirms recent findings of reduced circulating ionized magnesium but normal circulating total magnesium in adults with non-insulin-dependent diabetes mellitus.
胰岛素依赖型糖尿病是否为镁缺乏状态尚不清楚。这是一个相关问题，因为镁缺乏与在糖尿病中发展程度增加的疾病的发病机制有关。76例胰岛素依赖型糖尿病儿科患者的血浆总镁（0.77[0.73 - 0.81]mmol/L；中位数和四分位间距）、59例健康成年人（0.80[0.77 - 0.83]mmol/L）和19例健康儿童（0.80[0.78 - 0.83]mmol/L）之间无统计学差异。相比之下，血浆离子镁是生理和生物学特性方面最具意义的形式，与健康成年人（0.53[0.50 - 0.56]mmol/L；p < 0.01）和健康儿童（0.54[0.51 - 0.56]mmol/L；p < 0.02）相比，糖尿病患者的血浆离子镁显著降低（0.50[0.48 - 0.53]mmol/L）。我们的报告证实了近期关于非胰岛素依赖型糖尿病成年患者循环离子镁降低但循环总镁正常的研究结果。
