Sharma S S, Kochupillai V, Gupta S K, Seth S D, Gupta Y K
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
J Ethnopharmacol. 1997 Jul;57(2):93-6. doi: 10.1016/s0378-8741(97)00054-8.
Effect of ginger (Zingiber officinale Roscoe, Zingiberaceae) extracts (acetone, 50% ethanolic and aqueous) were investigated for antiemetic activity against emesis induced by 3 mg/kg cisplatin (the 100% emetic dose i.v.) in-healthy mongrel dogs. The acetone and 50% ethanolic extract at the doses of 25, 50, 100 and 200 mg/kg p.o. exhibited significant protection while aqueous extract at these doses was ineffective against cisplatin emesis. The acetone extract was more effective than ethanolic extract. However, both were less effective when compared to 5-HT3 receptors antagonist-granisetron. Neither of the ginger extract was effective against apomorphine-induced emesis. The findings suggest that ginger could be an effective and cheap antiemetic adjunct to cancer chemotherapy.
研究了姜（姜科植物姜Zingiber officinale Roscoe）提取物（丙酮提取物、50%乙醇提取物和水提取物）对健康杂种犬静脉注射3mg/kg顺铂（100%催吐剂量）诱导的呕吐的止吐活性。口服剂量为25、50、100和200mg/kg的丙酮提取物和50%乙醇提取物表现出显著的保护作用，而这些剂量的水提取物对顺铂诱导的呕吐无效。丙酮提取物比乙醇提取物更有效。然而，与5-HT3受体拮抗剂格拉司琼相比，两者的效果都较差。两种姜提取物对阿扑吗啡诱导的呕吐均无效。这些发现表明，姜可能是癌症化疗中一种有效且廉价的止吐辅助药物。
