Arumugam K, Lim J M
Department of Obstetrics and Gynaecology, University of Malaya, Kuala Lumpur.
Br J Obstet Gynaecol. 1997 Aug;104(8):948-50. doi: 10.1111/j.1471-0528.1997.tb14357.x.
This case-controlled study investigates whether the presence of menstrual characteristics, which may increase the exposure of the peritoneal cavity to retrograde menstruation, increases the risk of developing endometriosis. The menstrual characteristics considered were 1. age at menarche of less than 12 years, 2. duration of menstrual flow greater than five days and 3. menstrual cycle lengths of < 28 days. The frequency with which these menstrual characteristics occurred in 305 women with proven endometriosis was compared with their frequency in 305 age-matched women without endometriosis. Adjusting for the confounding factors of parity, age at first childbirth and social class, the only menstrual characteristic that was significantly associated with endometriosis was menstrual cycle lengths of less than 28 days (odds ratio 1.83; 95% confidence intervals 1.60-2.55). There was insufficient evidence to conclude that the presence of menstrual characteristics which may increase the exposure of the peritoneal cavity to retrograde menstruation, increase a women's risk of developing endometriosis. The association of short menstrual cycle lengths with endometriosis may have been consequential rather than causal.
这项病例对照研究调查了那些可能增加腹膜腔暴露于经血逆流情况的月经特征是否会增加患子宫内膜异位症的风险。所考虑的月经特征包括：1. 初潮年龄小于12岁；2. 月经持续时间超过5天；3. 月经周期长度小于28天。将这些月经特征在305名已确诊子宫内膜异位症的女性中的出现频率，与在305名年龄匹配的未患子宫内膜异位症的女性中的出现频率进行了比较。在对生育次数、初产年龄和社会阶层等混杂因素进行调整后，唯一与子宫内膜异位症显著相关的月经特征是月经周期长度小于28天（比值比1.83；95%置信区间1.60 - 2.55）。没有足够的证据得出结论，即那些可能增加腹膜腔暴露于经血逆流情况的月经特征会增加女性患子宫内膜异位症的风险。月经周期短与子宫内膜异位症之间的关联可能是继发的而非因果关系。
