Senden T J, Moock K H, Gerald J F, Burch W M, Browitt R J, Ling C D, Heath G A
Department of Physics, University College, University of New South Wales, Canberra, Australia.
J Nucl Med. 1997 Aug;38(8):1327-33.
Technegas, the discrete radio-aerosol particle, containing 99mTc has been investigated, and the chemical evolution and physical properties of the particle demonstrated.
A commercial technegas generator was used to produce aerosols according to standard clinical procedures. The aerosols were collected by electrostatic precipitation and examined with transition electron microscopy (TEM), scanning electron microscopy (SEM) and force microscopy. The chemical evolution was examined by x-ray techniques and thermogravimetric analysis.
The active particle was identified as hexagonal platelets of metallic technetium contained within a thin layer of graphitic carbon. This composite structure is discussed in light of the metal particle behaving as a template for the carbon capsule. The average size of the observed hexagonal platelets, 30-60 nm, was only weakly dependent on the concentration of technetium in the crucible.
The mechanism for the formation of the technegas pancreas has been developed and the particles involved characterized. It appears that the use of other metals also leads to the formation of similar materials.
已对含有99mTc的离散放射性气溶胶颗粒Technegas进行了研究，并展示了该颗粒的化学演变和物理性质。
使用商用Technegas发生器按照标准临床程序产生气溶胶。通过静电沉淀收集气溶胶，并用透射电子显微镜（TEM）、扫描电子显微镜（SEM）和力显微镜进行检查。通过X射线技术和热重分析检查化学演变。
活性颗粒被鉴定为包含在薄石墨碳层内的金属锝的六边形薄片。根据金属颗粒作为碳胶囊模板的行为对这种复合结构进行了讨论。观察到的六边形薄片的平均尺寸为30 - 60纳米，仅微弱依赖于坩埚中锝的浓度。
已阐明Technegas颗粒的形成机制，并对所涉及的颗粒进行了表征。似乎使用其他金属也会导致形成类似材料。
