Lemb M, Oei T H, Eifert H, Günther B
Rntgeninstitut Dres. Oei/Lemb/Wenz, Bremerhaven, Germany.
Eur J Nucl Med. 1993 Jul;20(7):576-9. doi: 10.1007/BF00176550.
Technegas (TcG) was produced using a commercially available TcG generator. The structure and size distribution of TcG particles were examined by means of the following methods: (a) transmission electron microscopy (TEM), range: 1 nm-100 microns; (b) time-of-flight mass spectroscopy (MS), range: < 3 nm; (c) photon correlation spectroscopy (PCS), range: 3 nm-3 microns. The TEM images showed graphite particles (size 7-23 nm) agglomerated into larger secondary aggregates. The size of these aggregates, determined from PCS and TEM measurements, showed a log-normal distribution and typically ranged from 60 to 160 nm. No isolated particles smaller than 3 nm could be detected by MS. We conclude that TcG particles consist of technetium-99m labelled agglomerated graphite particles and have an average size of 97 nm (geometrice standard deviation (GSD): 1.55).
锝气（TcG）使用市售的TcG发生器制备。通过以下方法检查TcG颗粒的结构和尺寸分布：（a）透射电子显微镜（TEM），范围：1纳米至100微米；（b）飞行时间质谱（MS），范围：<3纳米；（c）光子相关光谱（PCS），范围：3纳米至3微米。TEM图像显示石墨颗粒（尺寸7 - 23纳米）聚集成更大的二次聚集体。由PCS和TEM测量确定的这些聚集体的尺寸呈对数正态分布，通常范围为60至160纳米。MS未检测到小于3纳米的孤立颗粒。我们得出结论，TcG颗粒由99m锝标记的团聚石墨颗粒组成，平均尺寸为97纳米（几何标准偏差（GSD）：1.55）。
