Hansson C, Ahlfors S, Bergendorff O
Department of Dermatology, University Hospital, Lund, Sweden.
Contact Dermatitis. 1997 Jul;37(1):27-31. doi: 10.1111/j.1600-0536.1997.tb00370.x.
p-phenylenediamine derivatives are widely used in industry and in cosmetics, and several of them are well-known sensitizers. One group of allergenic p-phenylenediamine derivatives are used as colour film developers. Cross-reactivity between the colour film developers has been reported. In this paper, an occupational facial dermatitis due to colour film developers is described. The patient reacted to colour film developers (CD-1, CD-2, CD-3, and CD-4), but not to other p-phenylenediamine derivatives tested. He also showed allergic reactions to Disperse Blue 106 and Disperse Blue 124 and to Disperse Red 17, but not to Disperse Orange 3. The activation of the colour film developers by oxidation at physiological pH was analysed with chemical methods, and the mechanism responsible for the concomitant reactivities to the colour film developers and the disperse dyes at a molecular level is discussed.
对苯二胺衍生物广泛应用于工业和化妆品中，其中有几种是著名的致敏剂。一类具有致敏性的对苯二胺衍生物用作彩色胶片显影剂。已有报道称彩色胶片显影剂之间存在交叉反应。本文描述了一例因彩色胶片显影剂引起的职业性面部皮炎。该患者对彩色胶片显影剂（CD - 1、CD - 2、CD - 3和CD - 4）有反应，但对测试的其他对苯二胺衍生物无反应。他对分散蓝106、分散蓝124和分散红17也有过敏反应，但对分散橙3无反应。采用化学方法分析了彩色胶片显影剂在生理pH值下通过氧化的活化情况，并在分子水平上讨论了对彩色胶片显影剂和分散染料同时产生反应的机制。
