Lund University, Department of Occupational and Environmental Dermatology, Skane University Hospital, Malmö, Sweden.
Contact Dermatitis. 2020 Nov;83(5):387-390. doi: 10.1111/cod.13660. Epub 2020 Sep 14.
The textile dye mix (TDM) 6.6% pet. contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of p-phenylenediamine (PPD)-allergic dermatitis patients have shown positive patch test reactions to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of frequent, strong reactions to TDM 6.6% and PPD.
To study if DO 3 can be omitted from a TDM.
Patch tests were performed on 2250 dermatitis patients with TDM 6.6%, TDM 5.6% pet., TDM 7.0% pet., and PPD 1.0% pet.; 122 patients were also patch tested with DO 3 1.0% pet.
Among the 2250 patients patch tested, contact allergy prevalence to TDM 6.6% was 2.4%, to TDM 5.6% 1.8%, and to TDM 7.0% 2.0%. Of the 54 TDM 6.6%-positive patients, 55.6% reacted to PPD; as much as 42.2% of PPD-allergic women and 50% of PPD-allergic men reacted to TDM 6.6%. Of the 17 DO 3-positive patients, 94.1% showed a positive reaction to PPD.
Results indicate that DO 3 can probably be omitted from TDM, but patch testing with TDM 6.6%, TDM 7.0%, DO 3 1.0%, and PPD 1.0% simultaneously is needed to finally decide whether it is possible or not.
纺织染料混合物（TDM）6.6% pet. 含有分散蓝（DB）35、分散黄 3、分散橙（DO）1 和 3、分散红 1 和 17，以及 DB 106 和 124。在 TDM 阳性患者中，最常见的过敏原是 DO 3。大约 85%的对苯二胺（PPD）过敏性皮炎患者对 DO 3 的斑贴试验反应呈阳性。由于 TDM 6.6% 和 PPD 经常出现强烈反应，因此有人讨论将 DO 3 从 TDM 6.6% 中排除。
研究 DO 3 是否可以从 TDM 中排除。
对 2250 例 TDM 6.6%、TDM 5.6% pet.、TDM 7.0% pet.和 PPD 1.0% pet.的皮炎患者进行斑贴试验；122 例患者还进行了 DO 3 1.0% pet.的斑贴试验。
在接受斑贴试验的 2250 例患者中，对 TDM 6.6%的接触过敏患病率为 2.4%，对 TDM 5.6%为 1.8%，对 TDM 7.0%为 2.0%。在 54 例 TDM 6.6%阳性患者中，55.6%对 PPD 有反应；多达 42.2%的 PPD 过敏女性和 50%的 PPD 过敏男性对 TDM 6.6%有反应。在 17 例 DO 3 阳性患者中，94.1%对 PPD 有阳性反应。
结果表明，DO 3 可能可以从 TDM 中排除，但需要同时进行 TDM 6.6%、TDM 7.0%、DO 3 1.0%和 PPD 1.0%的斑贴试验，以最终确定是否可行。
