Barrett J C, Vainio H, Peakall D, Goldstein B D
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):699-737. doi: 10.1289/ehp.97105s4699.
The 12th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC) considered the topic of methodologies for determining human and ecosystem susceptibility to environmental hazards. The report prepared at the meeting describes measurement of susceptibility through the use of biological markers of exposure, biological markers of effect, and biomarkers directly indicative of susceptibility of humans or of ecosystems. The utility and validity of these biological markers for the study of susceptibility are evaluated, as are opportunities for developing newer approaches for the study of humans or of ecosystems. For the first time a SGOMSEC workshop also formally considered the issue of ethics in relation to methodology, an issue of particular concern for studies of susceptibility.
化学品安全评估方法科学小组（SGOMSEC）第十二次会议审议了确定人类和生态系统对环境危害易感性的方法这一主题。会议编写的报告描述了通过使用接触生物标志物、效应生物标志物以及直接指示人类或生态系统易感性的生物标志物来测量易感性。评估了这些生物标志物在易感性研究中的实用性和有效性，以及开发研究人类或生态系统新方法的机会。SGOMSEC研讨会还首次正式审议了与方法相关的伦理问题，这是易感性研究特别关注的一个问题。
