化学品安全评估方法科学小组第12次会议：对环境危害的易感性
12th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals: susceptibility to environmental hazards.
作者信息
Barrett J C, Vainio H, Peakall D, Goldstein B D
机构信息
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
出版信息
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):699-737. doi: 10.1289/ehp.97105s4699.
Abstract
The 12th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC) considered the topic of methodologies for determining human and ecosystem susceptibility to environmental hazards. The report prepared at the meeting describes measurement of susceptibility through the use of biological markers of exposure, biological markers of effect, and biomarkers directly indicative of susceptibility of humans or of ecosystems. The utility and validity of these biological markers for the study of susceptibility are evaluated, as are opportunities for developing newer approaches for the study of humans or of ecosystems. For the first time a SGOMSEC workshop also formally considered the issue of ethics in relation to methodology, an issue of particular concern for studies of susceptibility.
摘要
化学品安全评估方法科学小组（SGOMSEC）第十二次会议审议了确定人类和生态系统对环境危害易感性的方法这一主题。会议编写的报告描述了通过使用接触生物标志物、效应生物标志物以及直接指示人类或生态系统易感性的生物标志物来测量易感性。评估了这些生物标志物在易感性研究中的实用性和有效性，以及开发研究人类或生态系统新方法的机会。SGOMSEC研讨会还首次正式审议了与方法相关的伦理问题，这是易感性研究特别关注的一个问题。
相似文献
1
12th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals: susceptibility to environmental hazards.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):699-737. doi: 10.1289/ehp.97105s4699.
2
Methods for and approaches to evaluating susceptibility of ecological systems to hazardous chemicals.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):843-8. doi: 10.1289/ehp.97105s4843.
3
Biomarkers of exposure in community settings.
J Toxicol Environ Health A. 2004;67(8-10):715-26. doi: 10.1080/15287390490428198.
4
Human biomonitoring: state of the art.
Int J Hyg Environ Health. 2007 May;210(3-4):201-28. doi: 10.1016/j.ijheh.2007.01.024. Epub 2007 Mar 21.
5
Genetic susceptibility in ecosystems: the challenge for ecotoxicology.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):849-54. doi: 10.1289/ehp.97105s4849.
6
Evaluating legacy contaminants and emerging chemicals in marine environments using adverse outcome pathways and biological effects-directed analysis.
Mar Pollut Bull. 2013 Sep 30;74(2):517-25. doi: 10.1016/j.marpolbul.2013.06.012. Epub 2013 Jun 29.
7
Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan.
Toxicol Appl Pharmacol. 2005 Aug 7;206(2):198-206. doi: 10.1016/j.taap.2004.10.023.
8
Methodologies, bioindicators, and biomarkers for assessing gender-related differences in wildlife exposed to environmental chemicals.
Environ Res. 2007 May;104(1):135-52. doi: 10.1016/j.envres.2006.08.002. Epub 2007 Jan 4.
9
Human biological monitoring for exposure assessment in response to an incident involving hazardous materials.
Toxicol Lett. 2014 Dec 15;231(3):295-305. doi: 10.1016/j.toxlet.2014.03.002. Epub 2014 Mar 13.
10
Assessing biomarker use in risk assessment--a survey of practitioners.
J Toxicol Environ Health A. 2004;67(8-10):687-95. doi: 10.1080/15287390490428161.
引用本文的文献
1
Human Biomonitoring in the Oil Shale Industry Area in Estonia-Overview of Earlier Programmes and Future Perspectives.
Front Public Health. 2020 Nov 12;8:582114. doi: 10.3389/fpubh.2020.582114. eCollection 2020.
2
The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies.
AIMS Genet. 2017 Aug 11;4(3):166-191. doi: 10.3934/genet.2017.3.166. eCollection 2017.
3
Environmental Chemical Assessment in Clinical Practice: Unveiling the Elephant in the Room.
Int J Environ Res Public Health. 2016 Feb 2;13(2):181. doi: 10.3390/ijerph13020181.
4
Surface display of recombinant Drosophila melanogaster acetylcholinesterase for detection of organic phosphorus and carbamate pesticides.
PLoS One. 2013 Sep 9;8(9):e72986. doi: 10.1371/journal.pone.0072986. eCollection 2013.
5
Atorvastatin up-regulate toxicologically relevant genes in rainbow trout gills.
Ecotoxicology. 2012 Oct;21(7):1841-56. doi: 10.1007/s10646-012-0918-z. Epub 2012 May 4.
6
GSTT1 and GSTM1 gene polymorphisms in European and African populations.
Mol Biol Rep. 2011 Feb;38(2):1225-30. doi: 10.1007/s11033-010-0221-0. Epub 2010 Jun 20.
7
Applying bioethical principles to human biomonitoring.
Environ Health. 2008 Jun 5;7 Suppl 1(Suppl 1):S8. doi: 10.1186/1476-069X-7-S1-S8.
8
Applications of new technology in molecular epidemiology and their relevance to occupational medicine.
Occup Environ Med. 1999 Nov;56(11):725-9. doi: 10.1136/oem.56.11.725.
9
Effect of glutathione S-transferase M1 polymorphisms on biomarkers of exposure and effects.
Environ Health Perspect. 1998 Feb;106 Suppl 1(Suppl 1):231-9. doi: 10.1289/ehp.106-1533289.
本文引用的文献
1
Long-term ecosystem stress: the effects of years of experimental acidification on a small lake.
Science. 1985 Jun 21;228(4706):1395-401. doi: 10.1126/science.228.4706.1395.
2
Controlling Cotton's Insect Pests: A New System.
Science. 1982 Apr 2;216(4541):19-22. doi: 10.1126/science.216.4541.19.
3
Do scientific and scholarly codes of ethics take social issues into account?
Account Res. 1995;4(1):57-68. doi: 10.1080/08989629508573867.
4
A new type of hazardous chemical: the chemosensitizers of multixenobiotic resistance.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):855-60. doi: 10.1289/ehp.97105s4855.
5
Ethical, social, and legal issues surrounding studies of susceptible populations and individuals.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):837-41. doi: 10.1289/ehp.97105s4837.
6
Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):829-35. doi: 10.1289/ehp.97105s4829.
7
DNA adducts and mutations in occupational and environmental biomonitoring.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):823-7. doi: 10.1289/ehp.97105s4823.
8
Factors influencing susceptibility to metals.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):817-22. doi: 10.1289/ehp.97105s4817.
9
Biomarkers of gene expression: growth factors and oncoproteins.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):807-16. doi: 10.1289/ehp.97105s4807.
10
Biomarkers of human exposure to pesticides.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):801-6. doi: 10.1289/ehp.97105s4801.
Zotero 插件