细胞色素P450的基因多态性作为环境毒性易感性的生物标志物。
Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.
作者信息
Hong J Y, Yang C S
机构信息
College of Pharmacy, Rutgers University, Piscataway, New Jersey 08864, USA.
出版信息
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):759-62. doi: 10.1289/ehp.97105s4759.
Abstract
Cytochrome P450 (CYP) enzymes are responsible for the metabolism of numerous xenobiotics and endogenous compounds, including the metabolic activation of most environmental toxic chemicals and carcinogens. Both metabolic and genetic polymorphisms have been identified for human CYP enzymes. The association of CYP genetic polymorphism and human cancer risk, and susceptibility to environmental hazards, have received increasing attention. This article briefly reviews the approaches and methods currently used in CYP genetic polymorphism studies. In addition, the current status and perspectives of using CYP genetic polymorphism as a biomarker of individual susceptibility to cancer and environmental toxicity are discussed.
摘要
细胞色素P450（CYP）酶负责多种外源性物质和内源性化合物的代谢，包括大多数环境有毒化学物质和致癌物的代谢活化。已确定人类CYP酶存在代谢多态性和基因多态性。CYP基因多态性与人类癌症风险以及对环境危害的易感性之间的关联受到了越来越多的关注。本文简要回顾了目前CYP基因多态性研究中使用的方法。此外，还讨论了将CYP基因多态性用作个体对癌症和环境毒性易感性生物标志物的现状和前景。
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