Evenden A J, Depledge M H
Plymouth Environmental Research Centre, University of Plymouth, United Kingdom.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):849-54. doi: 10.1289/ehp.97105s4849.
Environmental management is inevitably complicated by the large variation in susceptibility to chemical toxicity exhibited by the living components of ecosystems, a significant proportion of which is determined by genetic factors. This paper examines the concept of genetic susceptibility in ecosystems and suggests the existence of two distinct forms reflecting genetic changes at the level of the individual and at the level of population and community. The influence of genetic susceptibility on exposure-response curves is discussed and the consequent accuracy of data used for toxicity test-based risk assessments examined. The paper concludes by describing a possible biomarker-based approach to future studies of susceptibility in ecosystems, suggesting the use of modern molecular genetic methods.
环境管理不可避免地因生态系统生物成分对化学毒性的易感性差异巨大而变得复杂，其中很大一部分是由遗传因素决定的。本文探讨了生态系统中遗传易感性的概念，并指出存在两种不同形式，分别反映个体层面以及种群和群落层面的遗传变化。讨论了遗传易感性对暴露-反应曲线的影响，并审视了基于毒性测试的风险评估所使用数据的准确性。本文最后描述了一种基于生物标志物的未来生态系统易感性研究方法，并建议使用现代分子遗传学方法。
