早期肺癌检测与干预方法的近期分子进展。
Recent molecular advances in the approach to early lung cancer detection and intervention.
作者信息
Mulshine J L, Scott F, Zhou J, Avis I, Vos M, Treston A M
机构信息
Division of Clinical Science, National Cancer Institute, Rockville, Maryland 20850-3300, USA.
出版信息
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):935-9. doi: 10.1289/ehp.97105s4935.
Abstract
Lung cancer is a major contributor to overall cancer mortality. Detecting lung cancer while it is still a localized process is a long-cherished goal for improving the outcome of this disease. Recent developments suggest that we are approaching this capability. We next have to think about how to implement a change in our approach to lung cancer management to derive the benefit of better detection capability. This is an area in which our growing understanding of lung cancer biology is providing clues on improving the inhibition of cancer progression.
摘要
肺癌是导致癌症总体死亡率的主要因素。在肺癌仍处于局部阶段时进行检测，是改善该疾病治疗结果长期以来所追求的目标。最近的进展表明，我们正在接近这一能力。接下来，我们必须思考如何在肺癌管理方法上做出改变，以从更好的检测能力中获益。在这一领域，我们对肺癌生物学不断加深的理解正在为改善对癌症进展的抑制提供线索。
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