一种新的细胞表面抗原在活化小鼠巨噬细胞上的表达。
Expression of a new cell surface antigen on activated murine macrophages.
作者信息
Kaplan A M, Mohanakumar T
出版信息
J Exp Med. 1977 Nov 1;146(5):1461-6. doi: 10.1084/jem.146.5.1461.
Abstract
A macrophage cell-surface antigen associated with pyran and Corynebacterium parvum-activated macrophages and P388D1 cells but not detectable on normal or glycogen and thioglycollate-elicited murine macrophages has been described. The antigen was demonstrated both by complement-mediated cytotoxicity and immunofluorescence, using an appropriately absorbed rabbit antiserum to P388D1. This antiserum should enable the characterization of activated macrophage cell populations on an individual cell basis and should be a useful probe to study the interactions of macrophages with tumor cells and the relationship of activation to cell-surface changes.
摘要
已描述了一种与吡喃及短小棒状杆菌激活的巨噬细胞和P388D1细胞相关的巨噬细胞表面抗原，但在正常或糖原及巯基乙酸盐诱导的小鼠巨噬细胞上无法检测到。使用经适当吸收的兔抗P388D1血清，通过补体介导的细胞毒性和免疫荧光法证实了该抗原。这种抗血清应能在单个细胞基础上对活化的巨噬细胞群体进行表征，并且应是研究巨噬细胞与肿瘤细胞相互作用以及激活与细胞表面变化关系的有用探针。
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