Navarro M, Cervera R, Font J, Reverter J C, Monteagudo J, Escolar G, López-Soto A, Ordinas A, Ingelmo M
Systemic Autoimmune Diseases Unit, Hospital Clinic, Barcelona, Catalonia, Spain.
Lupus. 1997;6(6):521-6. doi: 10.1177/096120339700600608.
To investigate the prevalence and characteristics of anti-endothelial cell antibodies (AECA) in a large cohort of patients with several well defined systemic autoimmune diseases, in order to determine their relationship with the clinical and laboratory features of these diseases.
Clinical and laboratory features of 216 consecutive Caucasian patients were prospectively studied. One hundred and seven patients had been diagnosed as having a primary systemic vasculitis-specifically, 39 had temporal arteritis (TA), 25 polyarteritis nodosa (PAN), 9 Wegener's granulomatosis (WG), and 34 Behcet's disease (BD)-, 90 patients had systemic lupus erythematosus (SLE), and 19 had a primary Sjogren's syndrome (SS). The AECA were determined by ELISA.
One hundred and four (48%) patients with systemic autoimmune diseases were found to have a positive titre of AECA. Specifically, AECA were detected in 41 (38%) patients with a primary systemic vasculitis (13 (33%) with TA, 14 (56%) with PAN, 5 (56%) with WG and 9 (26%) with BD), in 58 (63%) patients with SLE, and in 5 (26%) patients with a primary SS. In patients with a primary systemic vasculitis, those with AECA were found to have an increased prevalence of disease activity (P < 0.05). In SLE patients, those with AECA were found to have an increased prevalence of vascular lesions (P < 0.05), lupus nephropathy (P < 0.05), and anticardiolipin antibodies (aCL) (P < 0.001).
Patients with systemic autoimmune diseases have a high prevalence of AECA and they are associated with the presence of vascular lesions, nephropathy, and aCL in SLE, as well as with disease activity in several primary systemic vasculitis (TA, PAN, WG and BD).
在一大群患有多种明确系统性自身免疫性疾病的患者中，研究抗内皮细胞抗体（AECA）的患病率及特征，以确定其与这些疾病的临床和实验室特征之间的关系。
对216例连续的白种人患者的临床和实验室特征进行前瞻性研究。107例患者被诊断患有原发性系统性血管炎，具体为：39例患有颞动脉炎（TA），25例患有结节性多动脉炎（PAN），9例患有韦格纳肉芽肿病（WG），34例患有白塞病（BD）；90例患者患有系统性红斑狼疮（SLE），19例患有原发性干燥综合征（SS）。通过酶联免疫吸附测定（ELISA）法检测AECA。
发现104例（48%）患有系统性自身免疫性疾病的患者AECA滴度呈阳性。具体而言，在41例（38%）原发性系统性血管炎患者中检测到AECA（13例（33%）患有TA，14例（56%）患有PAN，5例（56%）患有WG，9例（26%）患有BD），在58例（63%）SLE患者中检测到AECA，在5例（26%）原发性SS患者中检测到AECA。在原发性系统性血管炎患者中，发现AECA阳性患者的疾病活动患病率增加（P < 0.05）。在SLE患者中，发现AECA阳性患者的血管病变患病率增加（P < 0.05）、狼疮性肾病患病率增加（P < 0.05）以及抗心磷脂抗体（aCL）患病率增加（P < 0.001）。
系统性自身免疫性疾病患者中AECA的患病率较高，并且它们与SLE中的血管病变、肾病和aCL的存在相关，也与几种原发性系统性血管炎（TA、PAN、WG和BD）的疾病活动相关。
