肺炎球菌素L-743,872对多种临床重要霉菌的体外抗真菌活性。
In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds.
作者信息
Del Poeta M, Schell W A, Perfect J R
机构信息
Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
Antimicrob Agents Chemother. 1997 Aug;41(8):1835-6. doi: 10.1128/AAC.41.8.1835.
Abstract
The in vitro activity of the new antifungal drug pneumocandin L-743,872 against 55 isolates of clinically important molds was examined by an adapted macrobroth dilution method for yeasts. Pneumocandin L-743,872 exhibited in vitro antifungal activity against Alternaria sp., Aspergillus flavus, Aspergillus fumigatus, Curvularia lunata, Exophiala jeanselmei, Fonsecaea pedrosoi, Paecilomyces variotii, and Scedosporium apiospermum. The drug appeared to lack significant in vitro inhibitory activity against Fusarium oxysporum, Fusarium solani, Rhizopus arrhizus, Paecilomyces lilacinus, and Scedosporium prolificans.
摘要
采用改良的酵母大肉汤稀释法，检测了新型抗真菌药物肺炎球菌素L-743,872对55株具有临床重要意义的霉菌的体外活性。肺炎球菌素L-743,872对链格孢属、黄曲霉、烟曲霉、新月弯孢霉、甄氏外瓶霉、裴氏瓶霉、拟青霉和尖端赛多孢菌表现出体外抗真菌活性。该药物似乎对尖孢镰刀菌、茄病镰刀菌、少根根霉、淡紫拟青霉和多育赛多孢菌缺乏显著的体外抑制活性。
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