el-Azzouni M Z
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
J Egypt Soc Parasitol. 1997 Aug;27(2):331-40.
Ivermectin is a potent macrolytic lactone causing paralysis in many nematodes and arthropods through an influx of chloride ions across cell membranes. This work was carried out to assess its effect against T. spiralis infection in Swiss albino mice as a single dose treatment. Ivermectin was administered to infected mice: one day before, the same day, 5, 10 and 35 days post Trichinella infection. Assessment of the drug effect was through: a) Parasitological study which included: adult count, Larval count, measurements of the length of the adult females, larvae and the reproductive capacity index; b) Scanning electron microscopic study of the adult & larva. Scanning EM changes were described, the results showed that it was most effective when administered on the same day of infection, its effect diminished progressively thereafter.
伊维菌素是一种强效的大环内酯类药物，通过氯离子跨细胞膜内流，使许多线虫和节肢动物麻痹。本研究旨在评估其作为单剂量治疗对瑞士白化小鼠旋毛虫感染的效果。将伊维菌素给予感染小鼠：在旋毛虫感染前一天、感染当天、感染后5天、10天和35天。通过以下方式评估药物效果：a）寄生虫学研究，包括：成虫计数、幼虫计数、成年雌性、幼虫长度测量以及生殖能力指数；b）成虫和幼虫的扫描电子显微镜研究。描述了扫描电镜变化，结果表明在感染当天给药时最有效，此后其效果逐渐减弱。
