Moore D H, Patterson H W, Hatch F, Discher D, Schneider J S, Bennett D, Mendelsohn M L
Lawrence Livermore National Laboratory, Livermore, California 94550, USA.
Am J Ind Med. 1997 Oct;32(4):377-91. doi: 10.1002/(sici)1097-0274(199710)32:4<377::aid-ajim9>3.0.co;2-r.
During 1972 to 1977, the Lawrence Livermore National Laboratory (LLNL) experienced increased diagnosis of malignant melanoma among employees. In 1984, a report on the results of a case-control study of 39 cases concluded that occupational factors, including exposures to ionizing radiation and to chemicals, caused the excess incidence. The study reported here, based on results from 69 case-control pairs, re-examines the role of the occupational factors implicated by the earlier study in melanoma causation. Results from this study suggest that constitutional factors, including skin reactivity to sunlight, sunbathing frequency, and number of moles, explain most of the excess melanoma. Exposures to occupational factors, including ionizing radiation and chemicals, were found to be no different in cases than in controls.
1972年至1977年期间，劳伦斯利弗莫尔国家实验室（LLNL）员工中恶性黑色素瘤的诊断病例有所增加。1984年，一份关于对39例病例进行病例对照研究结果的报告得出结论，职业因素，包括接触电离辐射和化学物质，导致了发病率过高。本文所报告的这项研究基于69对病例对照的结果，重新审视了早期研究中所涉及的职业因素在黑色素瘤病因中的作用。这项研究的结果表明，体质因素，包括皮肤对阳光的反应性、日光浴频率和痣的数量，解释了大部分黑色素瘤病例过多的原因。研究发现，病例组与对照组在接触包括电离辐射和化学物质在内的职业因素方面并无差异。
