Fujimura M, Sugawara T, Seki H, Otawara Y, Sakuma T, Nakano Y, Yoshimoto T
Department of Neurosurgery, Iwate Prefectural Central Hospital, Morioka.
Neurol Med Chir (Tokyo). 1997 Jul;37(7):546-50. doi: 10.2176/nmc.37.546.
A 57-year-old female who had had a mixed tumor of the submandibular gland for 30 years presented with a cranial metastasis in the ipsilateral occipital region. Detailed histological examinations of the primary tumor failed to detect any carcinomatous component. In contrast, the metastasis contained a carcinomatous component. This histological discrepancy was confirmed by assessment of the expression of Ki-67 antigen in these tumor specimens and comparison with five typical benign mixed tumors. Cranial metastasis of a histologically benign mixed tumor is extremely rare, and a carcinomatous change in the metastatic tumor is apparently unique.
一名患有下颌下腺混合瘤30年的57岁女性，出现同侧枕部颅骨转移。对原发肿瘤进行详细的组织学检查未发现任何癌性成分。相比之下，转移瘤中含有癌性成分。通过评估这些肿瘤标本中Ki-67抗原的表达并与五个典型的良性混合瘤进行比较，证实了这种组织学差异。组织学上良性的混合瘤发生颅骨转移极为罕见，而转移瘤中的癌性变化显然是独一无二的。
