Florin S, Leroux-Nicollet I, Meunier J C, Costentin J
Unité de Neuropsychopharmacologie Expérimentale, CNRS URA 1969, Institut Fédératif de Recherche Multidisciplinaire sur les Peptides, Faculté de Médecine et de Pharmacie de Rouen, Saint Etienne du Rouvray, France.
Neurosci Lett. 1997 Jul 11;230(1):33-6. doi: 10.1016/s0304-3940(97)00470-9.
The binding sites of [3H]nociceptin (also named Orphanin FQ), the endogenous ligand of the ORL1 (opiate receptor like 1) receptor, were localized in the central nervous system of the mouse using an autoradiographic procedure. A high density of binding sites was seen in the cerebral cortex, paraventricular nucleus of the thalamus, amygdaloid complex, suprachiasmatic nucleus, medial thalamus and medial geniculate nucleus. Moderate binding was observed in the nucleus accumbens, lateral septum, lateral thalamus, hippocampus, periaqueductal grey matter and pons. Finally, low levels of binding were seen in the striatum, olfactory tubercle, hypothalamus and substantia nigra. Thus, it appears that the ORL1 receptor is particularly abundant in the cerebral cortex and limbic system of the mouse brain.
使用放射自显影技术，将[3H]孤啡肽（也称为阿片样物质FQ）（ORL1（阿片样受体样1）受体的内源性配体）的结合位点定位在小鼠的中枢神经系统中。在大脑皮层、丘脑室旁核、杏仁复合体、视交叉上核、丘脑内侧和内侧膝状体中观察到高密度的结合位点。在伏隔核、外侧隔、外侧丘脑、海马、导水管周围灰质和脑桥中观察到中度结合。最后，在纹状体、嗅结节、下丘脑和黑质中观察到低水平的结合。因此，ORL1受体似乎在小鼠大脑的大脑皮层和边缘系统中特别丰富。
