亚硫酸氢盐在药物制剂中使用的注意事项。
Precautionary note for use of bisulfite in pharmaceutical formulations.
作者信息
Munson J W, Hussain A, Bilous R
出版信息
J Pharm Sci. 1977 Dec;66(12):1775-6. doi: 10.1002/jps.2600661234.
PMID:925948
Abstract
The effect of sodium bisulfite on aspirin hydrolysis was studied at 40 degrees in the pH range of 6.5-7.5. Significant catalytic activity by the sulfite ion was observed. Second-order rate constants were calculated for this catalysis and compared to other buffer species. The sulfite ion was a much more efficient catalyst than acetate, phosphate, or carbonate.
摘要
在40摄氏度、pH值为6.5 - 7.5的范围内研究了亚硫酸氢钠对阿司匹林水解的影响。观察到亚硫酸根离子具有显著的催化活性。计算了该催化反应的二级速率常数，并与其他缓冲物质进行了比较。亚硫酸根离子是比醋酸根、磷酸根或碳酸根更有效的催化剂。
相似文献
1
Precautionary note for use of bisulfite in pharmaceutical formulations.亚硫酸氢盐在药物制剂中使用的注意事项。
J Pharm Sci. 1977 Dec;66(12):1775-6. doi: 10.1002/jps.2600661234.
2
Kinetics of sulfite-induced anaerobic degradation of epinephrine.亚硫酸盐诱导的肾上腺素厌氧降解动力学
J Pharm Sci. 1975 Jan;64(1):45-8. doi: 10.1002/jps.2600640108.
3
Hydrolysis of nicotinyl 6-aminonicotinate.烟酰基6-氨基烟酸酯的水解
J Pharm Sci. 1986 Feb;75(2):204-7. doi: 10.1002/jps.2600750222.
4
Photoprotection of daunorubicin hydrochloride with sodium sulfite.亚硫酸钠对盐酸柔红霉素的光保护作用。
PDA J Pharm Sci Technol. 1995 May-Jun;49(3):122-6.
5
Sodium sulfite as an antioxidant in the acid hydrolysis of bovine pancreatic ribonuclease A.亚硫酸钠作为牛胰核糖核酸酶A酸水解中的抗氧化剂。
Anal Biochem. 1984 Sep;141(2):397-401. doi: 10.1016/0003-2697(84)90060-5.
6
The pepsin catalysed hydrolysis of bis-P-nitrophenyl sulfite.胃蛋白酶催化亚硫酸双对硝基苯酯的水解。
Biochem Biophys Res Commun. 1971 Oct 15;45(2):293-6. doi: 10.1016/0006-291x(71)90816-3.
7
Siroheme as an active catalyst in sulfite reduction.
J Biochem. 1981 Nov;90(5):1487-92. doi: 10.1093/oxfordjournals.jbchem.a133615.
8
On the mechanism of the pepsin-catalyzed hydrolysis of sulfite esters.
Biochemistry. 1972 Feb 15;11(4):592-600. doi: 10.1021/bi00754a018.
9
Deamination of cytosine derivatives by bisulfite. Mechanism of the reaction.亚硫酸氢盐对胞嘧啶衍生物的脱氨作用。反应机理。
J Am Chem Soc. 1974 Feb 6;96(3):906-12. doi: 10.1021/ja00810a043.
10
Kinetics and mechanism of hydrolysis of 1-(2'-acetoxybenzoyl)-2-deoxy-alpha-D-glucopyranose, a novel aspirin prodrug.新型阿司匹林前药1-(2'-乙酰氧基苯甲酰基)-2-脱氧-α-D-吡喃葡萄糖的水解动力学及机制
J Pharm Sci. 1979 Mar;68(3):299-301. doi: 10.1002/jps.2600680311.
引用本文的文献
1
Competitive inhibitory effect of external nucleophile concentration on intramolecular O- to N-acylation in O-acetylsalicylamide.外部亲核试剂浓度对O-乙酰水杨酰胺分子内O到N酰化的竞争性抑制作用。
AAPS PharmSciTech. 2000 Aug 19;1(3):E-TN1. doi: 10.1208/pt0103_tn1.
Zotero 插件