亚硫酸氢盐在药物制剂中使用的注意事项。

Precautionary note for use of bisulfite in pharmaceutical formulations.

作者信息

Munson J W, Hussain A, Bilous R

出版信息

J Pharm Sci. 1977 Dec;66(12):1775-6. doi: 10.1002/jps.2600661234.

Abstract

The effect of sodium bisulfite on aspirin hydrolysis was studied at 40 degrees in the pH range of 6.5-7.5. Significant catalytic activity by the sulfite ion was observed. Second-order rate constants were calculated for this catalysis and compared to other buffer species. The sulfite ion was a much more efficient catalyst than acetate, phosphate, or carbonate.

摘要

在40摄氏度、pH值为6.5 - 7.5的范围内研究了亚硫酸氢钠对阿司匹林水解的影响。观察到亚硫酸根离子具有显著的催化活性。计算了该催化反应的二级速率常数，并与其他缓冲物质进行了比较。亚硫酸根离子是比醋酸根、磷酸根或碳酸根更有效的催化剂。