Bachevalier J, Meunier M, Lu M X, Ungerleider L G
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland, USA.
Exp Brain Res. 1997 Jul;115(3):430-44. doi: 10.1007/pl00005713.
To determine the source of thalamic input to the medial aspect of the prefrontal cortex, we injected retrograde tracers (wheat germ agglutinin conjugated to horseradish peroxidase, nuclear yellow, and/or bisbenzimide) into seven medial prefrontal sites and anterograde tracers (tritiated amino acids) into six thalamic sites, in a total of nine rhesus monkeys. The results indicated that ventral precallosal and subcallosal areas 14 and 25, and the ventral, subcallosal part of area 32, all receive projections from the mediodorsal portion of the magnocellular division of the medial dorsal nucleus (MDmc). The dorsal, precallosal part of area 32 receives projections mainly from the dorsal portion of the parvocellular division of the medial dorsal nucleus (MDpc), which also provides some input to area 14. Polar area 10 receives input from both MDpc and the densocellular division of the medial dorsal nucleus (MDdc), as does supracallosal area 24. Area 24 receives additional input from the anterior medial nucleus and midline nuclei. All medial prefrontal cortical areas were also found to receive projections from a number of cortical regions within the temporal lobe, such as the temporal pole, superior temporal gyrus, and parahippocampal gyrus. Areas 24, 25, and 32 receive, in addition, input from the entorhinal cortex. Combining these results with prior anatomical and behavioral data, we conclude that medial temporal areas that are important for object recognition memory send information directly both to dorsal medial prefrontal areas 24 and 32 and to ventral medial prefrontal areas 14 and 25. Only the latter two areas have additional access to this information via projections from the mediodorsal part of MDmc.
为了确定丘脑向内侧前额叶皮质内侧区域的输入来源，我们在总共9只恒河猴中，向7个内侧前额叶部位注射逆行示踪剂（与辣根过氧化物酶结合的小麦胚芽凝集素、核黄和/或双苯甲酰亚胺），并向6个丘脑部位注射顺行示踪剂（氚标记氨基酸）。结果表明，胼胝体前腹侧和胼胝体下区域14和25，以及区域32的腹侧、胼胝体下部分，均接受来自内侧背核大细胞部（MDmc）内侧部分的投射。区域32的胼胝体前背侧部分主要接受来自内侧背核小细胞部（MDpc）背侧部分的投射，MDpc也向区域14提供一些输入。极区10接受来自MDpc和内侧背核致密细胞部（MDdc）的输入，胼胝体上区域24也是如此。区域24还接受来自前内侧核和中线核的额外输入。所有内侧前额叶皮质区域还被发现接受来自颞叶内多个皮质区域的投射，如颞极、颞上回和海马旁回。此外，区域24、25和32还接受来自内嗅皮质的输入。将这些结果与先前的解剖学和行为学数据相结合，我们得出结论，对物体识别记忆很重要的内侧颞叶区域直接将信息发送到内侧前额叶背侧区域24和32以及内侧前额叶腹侧区域14和25。只有后两个区域通过MDmc内侧部分的投射额外获取该信息。
