King D N, Heeley A F, Walsh M P, Kuzemko J A
Lancet. 1979 Dec 8;2(8154):1217-9. doi: 10.1016/s0140-6736(79)92336-5.
An immunoreactive-trypsin assay uses small dried-blood spots (diameter 1.25 mm) and is therefore suitable for incorporation in established neonatal screening schemes. Blood specimens from neonates with cystic fibrosis had trypsin levels greater than those in control subjects, thus confirming earlier findings. Trypsin levels were below normal in several older patients with cystic fibrosis.
免疫反应性胰蛋白酶测定使用小干血斑（直径1.25毫米），因此适用于纳入既定的新生儿筛查方案。囊性纤维化新生儿的血液标本中胰蛋白酶水平高于对照受试者，从而证实了早期的发现。几名年龄较大的囊性纤维化患者的胰蛋白酶水平低于正常水平。
