系统性红斑狼疮患者心率变异性降低。
Reduction in heart rate variability in patients with systemic lupus erythematosus.
作者信息
Laversuch C J, Seo H, Modarres H, Collins D A, McKenna W, Bourke B E
机构信息
Department of Rheumatology, St. George's Hospital, London, UK.
出版信息
J Rheumatol. 1997 Aug;24(8):1540-4.
OBJECTIVE
To determine whether heart rate variability and cardiovascular reflex tests are abnormal in patients with systemic lupus erythematosus (SLE).
METHODS
We measured heart rate variability (24 h ambulatory recordings), and used baroreflex sensitivity testing and cardiovascular reflex tests in a cross sectional, case-control study. Those taking drugs with cardiovascular activity were excluded.
RESULTS
Determination of heart rate variability was simple to perform, well tolerated, and found to be reduced in the patients with lupus, but not strongly related to disease activity or duration.
CONCLUSION
This may reflect underlying autonomic dysfunction; longitudinal studies will determine full clinical relevance.
目的
确定系统性红斑狼疮（SLE）患者的心率变异性和心血管反射测试是否异常。
方法
在一项横断面病例对照研究中，我们测量了心率变异性（24小时动态记录），并进行了压力反射敏感性测试和心血管反射测试。排除正在服用具有心血管活性药物的患者。
结果
心率变异性测定操作简单，耐受性良好，发现狼疮患者的心率变异性降低，但与疾病活动度或病程无密切关系。
结论
这可能反映了潜在的自主神经功能障碍；纵向研究将确定其全部临床相关性。
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