Orekhov A N, Grünwald J
Institute of Experimental Cardiology, Cardiology Research Center of the Russian Academy of Medical Sciences, Moscow, Russia.
Nutrition. 1997 Jul-Aug;13(7-8):656-63. doi: 10.1016/s0899-9007(97)83010-9.
This review discusses the use of garlic and garlic preparations as agents for prevention and treatment of atherosclerosis and atherosclerosis-related diseases. Garlic indirectly effects atherosclerosis by reduction of hyperlipidemia, hypertension, and probably diabetes mellitus and prevents thrombus formation. In addition, in animal models, garlic causes direct antiatherogenic (preventive) and antiatherosclerotic (causing regression) effects at the level of artery wall. Garlic's direct effect on atherosclerosis may be explained by its capacity to reduce lipid content in arterial cells and to prevent intracellular lipid accumulation. This effect, in turn, is accompanied by other atherosclerotic manifestations, i.e., stimulation of cell proliferation and extracellular matrix synthesis. Clinical trials are currently being carried out to reveal the possible effect of garlic therapy on human atherosclerosis. Positive results of these trials may open a new era in the use of garlic for prevention and treatment of many atherosclerosis-related diseases.
本综述讨论了大蒜及大蒜制剂作为预防和治疗动脉粥样硬化及动脉粥样硬化相关疾病药物的应用。大蒜通过降低高脂血症、高血压以及可能还有糖尿病来间接影响动脉粥样硬化，并预防血栓形成。此外，在动物模型中，大蒜在动脉壁水平产生直接的抗动脉粥样硬化（预防）和抗动脉粥样硬化（促使病变消退）作用。大蒜对动脉粥样硬化的直接作用可能是由于其降低动脉细胞脂质含量和防止细胞内脂质蓄积的能力。反过来，这种作用伴随着其他动脉粥样硬化表现，即刺激细胞增殖和细胞外基质合成。目前正在进行临床试验以揭示大蒜疗法对人类动脉粥样硬化可能产生的影响。这些试验的阳性结果可能会开创大蒜用于预防和治疗许多动脉粥样硬化相关疾病的新时代。
