Sobenin Igor A, Andrianova Irina V, Lakunin Konstantin Y, Karagodin Vasilii P, Bobryshev Yuri V, Orekhov Alexander N
Russian Cardiology Research and Production Complex, 121552 Moscow, Russia; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia.
Russian Cardiology Research and Production Complex, 121552 Moscow, Russia.
Phytomedicine. 2016 Oct 15;23(11):1235-9. doi: 10.1016/j.phymed.2015.10.014. Epub 2015 Nov 14.
Garlic (Allium sativum L.) is one of the most popular substances used to reduce various risks associated with cardiovascular disease. However, little is known on the direct effects of garlic on atherosclerosis.
In the present study we have examined the effect of per oral administration of the time-released garlic herbal preparation on serum atherogenicity and formation of intimal thickening after freeze injury in cholesterol-fed rabbits.
Group 1 rabbits maintained on the standard cholesterol-rich diet served as the control. Group 2 rabbits were fed the cholesterol-rich diet and treated with garlic preparation containing 300 mg garlic powder.
Local thickening of the aortic media (i.e., the neointima formation) in the freeze injury zone was observed in all the rabbits. Regular garlic preparation therapy prevented the neointima formation and the accumulation of free and esterified cholesterol, triglycerides, phospholipids and collagen in the neointima, the effects being statistically significant. Garlic preparation also decreased serum lipid content by 1.5-fold and lowered atherogenic activity of blood serum (ability to induce lipid accumulation in cultured cells) induced by cholesterol-rich diet.
The results obtained indicate that garlic preparation prevents the development of cholesterol-induced experimental atherosclerosis and possesses the direct anti-atherogenic activity.
大蒜（葱属植物大蒜）是用于降低与心血管疾病相关的各种风险的最常用物质之一。然而，关于大蒜对动脉粥样硬化的直接影响知之甚少。
在本研究中，我们研究了口服缓释大蒜草药制剂对胆固醇喂养的兔子血清致动脉粥样硬化性以及冷冻损伤后内膜增厚形成的影响。
第1组兔子维持标准高胆固醇饮食作为对照。第2组兔子喂食高胆固醇饮食并用含有300毫克大蒜粉的大蒜制剂治疗。
在所有兔子中均观察到冷冻损伤区域主动脉中层的局部增厚（即新生内膜形成）。常规大蒜制剂治疗可防止新生内膜形成以及新生内膜中游离和酯化胆固醇、甘油三酯、磷脂和胶原蛋白的积累，这些影响具有统计学意义。大蒜制剂还使血清脂质含量降低了1.5倍，并降低了高胆固醇饮食诱导的血清致动脉粥样硬化活性（在培养细胞中诱导脂质积累的能力）。
所得结果表明，大蒜制剂可预防胆固醇诱导的实验性动脉粥样硬化的发展，并具有直接的抗动脉粥样硬化活性。
