在F344大鼠中，通过给予牛乳铁蛋白抑制偶氮甲烷引发的结肠肿瘤。
Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats.
作者信息
Sekine K, Watanabe E, Nakamura J, Takasuka N, Kim D J, Asamoto M, Krutovskikh V, Baba-Toriyama H, Ota T, Moore M A, Masuda M, Sugimoto H, Nishino H, Kakizoe T, Tsuda H
机构信息
Chemotherapy Division, National Cancer Center Research Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1997 Jun;88(6):523-6. doi: 10.1111/j.1349-7006.1997.tb00413.x.
Abstract
The influence of bovine lactoferrin (bLF) on colon carcinogenesis was investigated in male F344 rats treated with azoxymethane (AOM). Following three weekly injections of AOM, the animals received 2 or 0.2% bLF for 36 weeks. No effects indicative of toxicity were noted, but significant reduction in both the incidence and number of adenocarcinomas of the large intestine was observed with both doses. Thus, the incidences of adenocarcinomas in the groups receiving 2% and 0.2% bLF were 15% and 25%, respectively, in contrast to the 57.5% control value (P < 0.01 and P < 0.05, respectively). The results indicate that bLF might find application for chemoprevention of colon cancer.
摘要
研究了牛乳铁蛋白（bLF）对用偶氮甲烷（AOM）处理的雄性F344大鼠结肠癌发生的影响。在每周注射3次AOM后，动物接受2%或0.2%的bLF，持续36周。未观察到毒性迹象，但两种剂量均使大肠腺癌的发生率和数量显著降低。因此，接受2%和0.2%bLF组的腺癌发生率分别为15%和25%，而对照组为57.5%（P分别<0.01和P<0.05）。结果表明，bLF可能可用于结肠癌的化学预防。
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