Zwicker C, Hering M, Langer R
Abteilung Computertomographie und Kernspintomographie, Hegau Klinikum, Virchowstrasse 10, D-78224 Singen, Germany.
Eur Radiol. 1997;7(7):1123-6. doi: 10.1007/s003300050266.
The purpose of this work was to evaluate the enhancement of different concentrations of gadolinium (Gd), ytterbium (Yb) and iodine in vitro and in vivo. Comparisons were made of the enhancement (HU) of Gd, Yb and iodine in concentrations ranging from 0.1 to 30 mg/ml. In vivo dynamic CT studies were performed in ten dogs with 0.5 M Gd, Yb and iodine. Time-density curves were achieved in aorta and liver. The in vitro studies confirmed a decrease in the enhancement in this order: Gd (120 kV) > Gd (137 kV) > Yb (120 kV) > Yb (137 kV) > iodine (120 kV) > iodine (137 kV). The specific enhancement of Gd was 40.8 (120 kV), of Yb 34.2 and of iodine 29.6 HU. The enhancement of the liver decreases from 21 HU (Gd) to 19 HU (Yb) and 12 HU (iodine). Gd and Yb achieved a higher aortal enhancement than iodine (190 vs 157 HU) All contrast media were well tolerated. Equimolar concentrations of Gd and Yb show a higher in vitro contrast and enhancement than iodine.
这项工作的目的是评估不同浓度的钆（Gd）、镱（Yb）和碘在体外和体内的增强效果。对浓度范围为0.1至30mg/ml的Gd、Yb和碘的增强效果（HU）进行了比较。对10只狗进行了体内动态CT研究，分别注射0.5M的Gd、Yb和碘。获得了主动脉和肝脏的时间-密度曲线。体外研究证实增强效果按以下顺序降低：Gd（120 kV）> Gd（137 kV）> Yb（120 kV）> Yb（137 kV）>碘（120 kV）>碘（137 kV）。Gd的特定增强效果为40.8（120 kV），Yb为34.2，碘为29.6 HU。肝脏的增强效果从21 HU（Gd）降至19 HU（Yb）和12 HU（碘）。Gd和Yb的主动脉增强效果高于碘（190对157 HU）。所有造影剂的耐受性良好。等摩尔浓度的Gd和Yb在体外显示出比碘更高的对比度和增强效果。
