Antonescu C R, Terzakis J A
Department of Pathology, Lenox Hill Hospital, New York, NY 10021, USA.
J Cutan Pathol. 1997 Aug;24(7):449-53. doi: 10.1111/j.1600-0560.1997.tb00822.x.
This unusual case is that of a middle-aged man exhibiting a tumor diathesis including a basal cell adenocarcinoma with features of adenoid cystic carcinoma arising in minor salivary gland of lip in association with multiple primary malignant cylindromas of skin. The labial lesion showed invasive tubules, solid epithelial sheets and cribriform structures. It did not exhibit PAS positive juxta-tubular basement membrane material. The skin lesions all showed features of a highly infiltrative cylindromatous carcinoma with two cell types, peripheral palisading and prominent PAS positive juxta-tubular basement membrane material. Immunocytochemical studies of the lip lesion and one of the skin lesions showed similarities, including positive staining for high and low molecular weight keratins and S-100 with negative staining for CEA. The precious descriptions of tumor diatheses involving dermal cylindromas and dermal analogue tumors of salivary glands and the distinctions with the present study are noted. If benign and even malignant cylindromas were described in the literature to be associated with basal cell adenocarcinoma of the major salivary glands, our case is unique by its association with this rare malignant tumor in a minor salivary gland.
该罕见病例为一名中年男性，表现出肿瘤素质，包括唇部小涎腺发生的具有腺样囊性癌特征的基底细胞腺癌，同时伴有皮肤多发性原发性恶性圆柱瘤。唇部病变显示浸润性小管、实性上皮片和筛状结构。其未显示PAS阳性的近小管基底膜物质。皮肤病变均表现为具有两种细胞类型的高度浸润性圆柱瘤样癌的特征，外周呈栅栏状排列，并有显著的PAS阳性近小管基底膜物质。对唇部病变和其中一个皮肤病变进行的免疫细胞化学研究显示出相似性，包括高分子量和低分子量角蛋白及S-100呈阳性染色，而癌胚抗原呈阴性染色。文中提到了以往关于涉及皮肤圆柱瘤和涎腺皮肤样肿瘤的肿瘤素质的描述以及与本研究的区别。如果文献中曾描述良性甚至恶性圆柱瘤与大涎腺基底细胞腺癌有关，那么我们的病例因其与小涎腺中这种罕见恶性肿瘤相关而独具特色。
