Vykhovanets E V, Chernyshov V P, Slukvin I I, Antipkin Y G, Vasyuk A N, Klimenko H F, Strauss K W
Laboratory of Immunology, Institute of Pediatrics, Obstetrics and Gynecology, Kiev, Ukraine.
Clin Immunol Immunopathol. 1997 Sep;84(3):251-9. doi: 10.1006/clin.1997.4379.
We assessed the major lymphocyte subsets in the peripheral blood, thyroid ultrasonography, levels of serum autoantibodies to thyroglobulin (AbTg), thyroid hormones, and thyroid-stimulating hormone (TSH) in 53 children without any chronic diseases living continuously around Chernobyl. The subjects ranged in age from 7 to 14 years and had different doses of 131I to their thyroid. Healthy children living on noncontaminated areas were assessed as controls. The majority of children with doses of 131I had normal levels of thyroid hormones. However, the percentages of positive sera for AbTg, TSH levels, ultrasonographic thyroid abnormalities, and abnormal echogenicity were significantly higher in children with doses of 131I than in controls. The dose of 131I to thyroid correlated positively with serum AbTg levels, percentage of CD3+CD4+ cells, and CD3+CD4+/CD3+CD8+ cell ratio and negatively with number of CD3+CD8+ and CD3-/CD16, CD56+ cells. Thus, our study demonstrates an association between dose of 131I and autoimmune thyroid disorders in this population of children.
我们评估了53名长期居住在切尔诺贝利周边、无任何慢性疾病的儿童的外周血主要淋巴细胞亚群、甲状腺超声检查结果、血清甲状腺球蛋白自身抗体（AbTg）水平、甲状腺激素水平以及促甲状腺激素（TSH）水平。这些受试者年龄在7至14岁之间，甲状腺接受了不同剂量的131I照射。将生活在未受污染地区的健康儿童作为对照。大多数接受131I照射的儿童甲状腺激素水平正常。然而，接受131I照射的儿童中，AbTg阳性血清的百分比、TSH水平、甲状腺超声异常以及回声异常的比例显著高于对照组。甲状腺接受的131I剂量与血清AbTg水平、CD3 + CD4 +细胞百分比以及CD3 + CD4 + / CD3 + CD8 +细胞比值呈正相关，与CD3 + CD8 +细胞数量以及CD3 - / CD16、CD56 +细胞数量呈负相关。因此，我们的研究表明在这群儿童中，131I剂量与自身免疫性甲状腺疾病之间存在关联。
