Singh V, Brockbank M J, Todd G B
Department of Otolaryngology, Salisbury District Hospital, UK.
J Laryngol Otol. 1997 Jul;111(7):616-8. doi: 10.1017/s0022215100138125.
Prior to flexible transnasal endoscopy (FTE) topical intranasal agents such as cocaine or combinations of a local anaesthetic and vasoconstrictor agent are generally recommended for local anaesthesia, easier access, and better examination of the interior of the nose, especially the middle meatus. This double-blind study involved 60 patients. Each had five per cent cocaine sprayed in one nostril and normal saline in the other. The pain/discomfort and gag scores showed no statistical difference. Forty-two (70 per cent) patients had a moderate/marked deviation of the nasal septum. A significant pain score (3-5) was obtained in 33.3 per cent of cases with the deviation towards the cocaine side and in 37 per cent of cases with the deviation towards the saline side. Ease of procedure scores for both sides were also comparable, when deviation of the nasal septum was taken into account.
在进行软性经鼻内镜检查（FTE）之前，通常建议使用鼻内局部用药，如可卡因或局部麻醉药与血管收缩剂的组合，以进行局部麻醉、便于操作并更好地检查鼻腔内部，尤其是中鼻道。这项双盲研究涉及60名患者。每位患者一侧鼻孔喷入5%的可卡因，另一侧喷入生理盐水。疼痛/不适和恶心评分无统计学差异。42名（70%）患者有中度/明显的鼻中隔偏曲。鼻中隔偏向可卡因侧的病例中有33.3%、偏向生理盐水侧的病例中有37%获得了显著的疼痛评分（3 - 5分）。考虑到鼻中隔偏曲时，两侧的操作难易程度评分也相当。
