van Buchem M A, Udupa J K, McGowan J C, Miki Y, Heyning F H, Boncoeur-Martel M P, Kolson D L, Polansky M, Grossman R I
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
AJNR Am J Neuroradiol. 1997 Aug;18(7):1287-90.
We report a semiautomated postprocessing method based on magnetization transfer MR imaging that can quantify the extent of global disease in patients with multiple sclerosis. The technique combines segmentation and quantitative analysis of imaging data reflecting the structural integrity of white matter. Applications of this technique may include assessment of disease progress and of the efficacy of experimental therapeutic intervention. The height of the histogram peak corresponding to white matter was found to be lowered in patients with multiple sclerosis and the overall distribution of magnetization transfer ratios was shifted to lower values.
我们报告了一种基于磁化传递磁共振成像的半自动后处理方法，该方法可量化多发性硬化症患者的整体疾病程度。该技术结合了对反映白质结构完整性的成像数据的分割和定量分析。该技术的应用可能包括评估疾病进展和实验性治疗干预的疗效。在多发性硬化症患者中，发现对应于白质的直方图峰值高度降低，并且磁化传递率的总体分布向较低值偏移。
