Seo M S, Yoon K C, Park Y G
Department of Ophthalmology, Chonnam National University Medical School & Hospital, Chonnam Research Institute of Medical Sciences, Kwangju, Korea.
Korean J Ophthalmol. 1997 Jun;11(1):70-3. doi: 10.3341/kjo.1997.11.1.70.
After the injection of about 10 gm of dapsone, a 38-year-old male showed a whitish-yellow patch in the macular region of both eyes, with decreased visual acuity of the counting finger in the right and 0.04 in the left eye. Two weeks after the start of systemic steroid therapy the patch disappeared, and on follow-up at 11 months, visual acuity was 0.02 in the right and 0.08 in the left eye, with macular degeneration and foveal nonperfusion. This retinal damage seems to be ischemic in origin and to be caused by a combination of acute severe peripheral hypoxemia and the vascular obstructive effect of red cell fragmentation resulting from massive hemolysis.
注射约10克氨苯砜后，一名38岁男性双眼黄斑区出现灰白色斑块，右眼视力降至数指，左眼视力为0.04。全身类固醇治疗开始两周后，斑块消失，在11个月的随访中，右眼视力为0.02，左眼视力为0.08，伴有黄斑变性和黄斑中心凹无灌注。这种视网膜损伤似乎起源于缺血，是由急性严重外周低氧血症和大量溶血导致的红细胞破碎的血管阻塞作用共同引起的。
