Kenner D J, Holt K, Agnello R, Chester G H
Br J Ophthalmol. 1980 Oct;64(10):741-4. doi: 10.1136/bjo.64.10.741.
A massive dose of 7.5 g of 4,4'-diamino, diphenyl sulphone (dapsone) taken as a suicide attempt in a patient on long-term therapy for tuberculoid leprosy resulted in permanent bilateral retinal necrosis, previously unreported side effect of this drug. The patient developed a severe haemolytic anaemia, methaemoglobinaemia, and acute renal failure requiring peritoneal dialysis. It is proposed that the retinal damage was due to a combination of severe hypoxaemia and the physical effects of red cell fragmentation producing vascular occlusion in the macular and perimacular region, with consequent ischaemic necrosis.
一名长期接受结核样型麻风病治疗的患者，试图服用7.5克大剂量的4,4'-二氨基二苯砜（氨苯砜）自杀，导致双侧视网膜永久性坏死，这是该药物此前未报告的副作用。该患者出现了严重的溶血性贫血、高铁血红蛋白血症和需要腹膜透析的急性肾衰竭。据推测，视网膜损伤是由于严重低氧血症以及红细胞破碎产生的物理效应导致黄斑和黄斑周围区域血管闭塞，进而引起缺血性坏死共同作用的结果。
