Yamagata N, Shimazaki C, Kikuta T, Hirai H, Sumikuma T, Sudo Y, Ashihara E, Goto H, Inaba T, Fujita N, Nakagawa M
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Cancer Genet Cytogenet. 1997 Sep;97(2):90-3. doi: 10.1016/s0165-4608(96)00339-1.
Only a small number of reports have described the cytogenetic analysis of minimally differentiated acute myeloid leukemia (AML, M0). We performed a cytogenetic analysis on a patient with AML (M0) with a normal platelet count. It revealed a chromosomal translocation between chromosome bands 3q21 and 12q24. 3q. Abnormalities in AML are known to be associated with normal or elevated platelet counts. 3q21 and 12q24 are common translocation sites in AML patients, but this is the first report of translocation t(3;12)(q21;q24) in an AML patient.
仅有少数报告描述了微分化急性髓系白血病（AML，M0）的细胞遗传学分析。我们对一名血小板计数正常的AML（M0）患者进行了细胞遗传学分析。结果显示3号染色体q21带和12号染色体q24带之间存在染色体易位，即t(3;12)(q21;q24)。已知AML中的异常与血小板计数正常或升高有关。3q21和12q24是AML患者常见的易位位点，但这是首次报道AML患者中出现t(3;12)(q21;q24)易位。
