溶血巴斯德菌白细胞毒素转录的一种假定亮氨酸拉链激活剂及其通过滑链错配调节其合成的可能性。
A putative leucine zipper activator of Pasteurella haemolytica leukotoxin transcription and the potential for modulation of its synthesis by slipped-strand mispairing.
作者信息
Highlander S K, Hang V T
机构信息
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Infect Immun. 1997 Sep;65(9):3970-5. doi: 10.1128/iai.65.9.3970-3975.1997.
Abstract
A Pasteurella haemolytica cosmid clone that activates leukotoxin transcription in Escherichia coli has been isolated. The activator locus, alxA, is part of a continuous open reading frame that includes the type I hsdM methylase gene. AlxA and HsdM peptides are processed from a precursor, and translation of the polyprotein can be modulated by slipped-strand mispairing across a pentanucleotide repeat, ACAGC, within the 5' end of alxA-hsdM. Extracts containing AlxA can bind to a leukotoxin promoter fragment.
摘要
已分离出一种能在大肠杆菌中激活白细胞毒素转录的溶血巴斯德氏菌黏粒克隆。激活位点alxA是一个连续开放阅读框的一部分，该阅读框包括I型hsdM甲基化酶基因。AlxA和HsdM肽从前体加工而来，多聚蛋白的翻译可通过alxA - hsdM 5'端五核苷酸重复序列ACAGC上的滑链错配进行调节。含有AlxA的提取物可与白细胞毒素启动子片段结合。
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