Sasaki N, Matsui A, Momoi M, Tsuda F, Okamoto H
Department of Pediatrics, Jichi Medical School, Tochigi-Ken, Japan.
Pediatr Res. 1997 Sep;42(3):263-7. doi: 10.1203/00006450-199709000-00003.
Of the 15 babies born to mothers infected with hepatitis C virus (HCV) and followed since birth, three developed HCV RNA in their serum. HCV RNA disappeared in two infants within 2 mo, but it persisted in the remaining infant. Mother-to-baby transmission was diagnosed retrospectively in an additional eight children aged 0.8-13.6 y. The eight children were followed for 1.4-5.0 y (mean +/- SD: 3.2 +/- 1.3 y) until they were 3.3-16.7 y old (8.5 +/- 4.3 y). Serum HCV RNA disappeared and antibodies to HCV decreased in the titer in two of the children when they were 3 y old. The spontaneous loss of serum HCV RNA was not observed in any of the other 14 children with posttransfusion infection who were followed for 2.6-6.1 y (4.0 +/- 1.1 y), until 3-22 y from the time they received transfusions and when they were 8.4-22.8 y old (15.4 +/- 4.1 y). These results indicate that the vertical transmission of HCV is rare, and some children can resolve the infection after a few years, whereas the infection persists in children who are infected by transfusion.
在15名感染丙型肝炎病毒（HCV）且自出生起就接受随访的婴儿中，有3名婴儿血清中出现了HCV RNA。其中2名婴儿在2个月内HCV RNA消失，但另1名婴儿的HCV RNA持续存在。另外8名年龄在0.8至13.6岁的儿童经回顾性诊断存在母婴传播。这8名儿童接受了1.4至5.0年（平均±标准差：3.2±1.3年）的随访，直至他们3.3至16.7岁（8.5±4.3岁）。其中2名儿童在3岁时血清HCV RNA消失且抗HCV滴度下降。在另外14名接受输血感染的儿童中，没有观察到血清HCV RNA自然消失的情况，这些儿童接受了2.6至6.1年（4.0±1.1年）的随访，从接受输血时起至3至22岁，当时他们8.4至22.8岁（15.4±4.1岁）。这些结果表明，HCV的垂直传播很少见，一些儿童在几年后可以清除感染，而输血感染的儿童感染会持续存在。
