喂养方式对豚鼠乙醇摄入量的影响。

Effects of feeding regimen on ethanol intake by guinea pigs.

作者信息

Poling A, Urbain C, Thompson T

出版信息

Pharmacol Biochem Behav. 1977 Oct;7(4):401-3. doi: 10.1016/0091-3057(77)90237-4.

Abstract

During daily two-hr sessions, guinea pigs licked a drinking tube filled with either 0 (tap water), 2,4 or 8% (v/v) ethanol solution under three feeding regimens. Consumption of each solution was highest when sufficient food to maintain subjects at 90% of free-feeding weight was provided during sessions, lower when the same food ration was provided after sessions, and lowest when ad lib access to food was provided within and between sessions. However, this decrease in consumption across feeding regimens was inversely related to ethanol concentration. Under all feeding regimens, volume of solution consumed decreased with increasing ethanol concentration while milligrams ethanol consumed increased with ethanol concentration. These results are similar in some respects to previous findings with rats and monkeys, suggesting that further studies of oral ethanol self-administration by guinea pigs may be merited.

摘要

在每天两小时的实验过程中，豚鼠在三种喂食方案下舔舐装有0（自来水）、2%、4%或8%（v/v）乙醇溶液的饮水管。当在实验过程中提供足够的食物以使实验对象维持在自由进食体重的90%时，每种溶液的摄入量最高；当在实验结束后提供相同的食物定量时，摄入量较低；而当在实验过程中和实验间隙都提供自由进食的食物时，摄入量最低。然而，不同喂食方案下摄入量的这种减少与乙醇浓度呈负相关。在所有喂食方案下，随着乙醇浓度的增加，溶液的摄入量减少，而摄入的乙醇毫克数随乙醇浓度的增加而增加。这些结果在某些方面与之前对大鼠和猴子的研究结果相似，这表明对豚鼠口服乙醇自我给药的进一步研究可能是有价值的。