Henningfield J E, Meisch R A
Pharmacol Biochem Behav. 1979 May;10(5):777-82. doi: 10.1016/0091-3057(79)90332-0.
Three monkeys were provided concurrent access to water and ethanol in concentrations of either 8, 16 or 32% (w/v) during daily 3-hr sessions. The monkeys were those for whom ethanol had been established as a reinforcer in an earlier study in which only ethanol or water was available. Ethanol was preferred to water at all concentrations and volume of ethanol consumed was inversely related to ethanol concentration. Quantity of ethanol (g/kg of body wt.) consumed remained relatively constant, and blood ethanol determinations confirmed that the monkeys were drinking ethanol. Water drinking occurred at negligible levels except by one monkey at 16 and 32% who followed ethanol drinking bouts by water bouts (chasers) in a manner similar to that reported in other studies. Two monkeys were also provided concurrent access to 8% ethanol and water during 23-hr daily sessions. Under these conditions, ethanol was consumed every few hours to the near exclusion of water. The significance of this study lies largely in its procedure; that is, the development and application of a concurrent water-ethanol preparation in which ethanol serves as a reinforcer for rhesus monkeys. This preparation should be useful in the evaluation of a wide range of factors suspected to control alcoholic drinking.
在每天3小时的时间段内，为三只猴子同时提供浓度为8%、16%或32%（重量/体积）的水和乙醇。这些猴子是在早期一项研究中已确定乙醇为强化物的猴子，在该研究中只有乙醇或水可供选择。在所有浓度下，猴子都更喜欢乙醇，且乙醇的消耗量与乙醇浓度呈反比。乙醇的消耗量（克/千克体重）保持相对恒定，血液乙醇测定证实猴子在饮用乙醇。除了一只猴子在16%和32%浓度时，在饮用乙醇后接着饮水（追逐），这种方式与其他研究报道的类似，饮水水平可以忽略不计。在每天23小时的时间段内，也为另外两只猴子同时提供8%的乙醇和水。在这些条件下，每隔几个小时就会消耗乙醇，几乎不喝水。这项研究的意义主要在于其程序；也就是说，开发并应用了一种水 - 乙醇同时供应的制备方法，其中乙醇作为恒河猴的强化物。这种制备方法在评估各种被怀疑控制酒精饮用的因素方面应该是有用的。
