Philbin E F, Cotto M, Rocco T A, Jenkins P L
Cardiac Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.
Am J Cardiol. 1997 Aug 15;80(4):519-22. doi: 10.1016/s0002-9149(97)00409-8.
Because the impact of diuretic use on mortality in acute congestive heart failure (CHF) is not known, we examined the association between drug use, fluid balance, and death among 1,150 patients hospitalized for evaluation and treatment of CHF. After adjusting for other relevant intergroup differences, we observed that less net weight loss and a greater number of intravenous drug doses retained significant predictive value for death, suggesting that more frequent diuretic dosing or diuretic resistance may be related to mortality in acute CHF.
由于利尿剂使用对急性充血性心力衰竭（CHF）死亡率的影响尚不清楚，我们研究了1150名因CHF评估和治疗而住院的患者的药物使用、液体平衡与死亡之间的关联。在对其他相关组间差异进行调整后，我们观察到较少的净体重减轻和较多的静脉用药剂量对死亡具有显著的预测价值，这表明更频繁的利尿剂给药或利尿剂抵抗可能与急性CHF的死亡率有关。
