Hadfield R M, Yudkin P L, Coe C L, Scheffler J, Uno H, Barlow D H, Kemnitz J W, Kennedy S H
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, UK.
Hum Reprod Update. 1997 Mar-Apr;3(2):109-15. doi: 10.1093/humupd/3.2.109.
The autopsy records between 1980 and 1995 of 399 female rhesus monkeys (Macaca mulatta) at the Wisconsin Regional Primate Research Center were examined. Spontaneous endometriosis was found in 81 (20%) of the animals. The mean (+/- SD) ages at death for animals with and without endometriosis were 20.7 +/- 5.5 (range 10-35) and 13.4 +/- 7.7 (range 4-37) years respectively. Many of the animals had been exposed to experimental procedures, including laparoscopies, hysterotomies and oestradiol implants, and these were examined as possible risk factors for endometriosis. Of the 81 affected animals, 62 were matched to unaffected controls for age at death (to within 1 year) and year of death (to within 2 years) and the effect of various factors on the development of endometriosis was determined using conditional logistic regression. Exposure to three or more oestradiol implants or one or more hysterotomies were both significant risk factors, with estimated relative risks of 9.7 (95% confidence interval 2.5-37.2) and 5.8 (95% confidence interval 1.6-20.2) respectively. Animals that had been exposed to one or more laparoscopies showed no increased risk for developing endometriosis. These findings provide insight into the aetiology of the disease in women. ?2P51 4RR00167
对威斯康星地区灵长类动物研究中心1980年至1995年间399只雌性恒河猴（猕猴）的尸检记录进行了检查。在81只（20%）动物中发现了自发性子宫内膜异位症。患有和未患有子宫内膜异位症的动物死亡时的平均（±标准差）年龄分别为20.7±5.5岁（范围10 - 35岁）和13.4±7.7岁（范围4 - 37岁）。许多动物曾接受过实验操作，包括腹腔镜检查、子宫切开术和雌二醇植入，对这些操作作为子宫内膜异位症可能的风险因素进行了检查。在81只受影响的动物中，62只与未受影响的对照在死亡年龄（相差1年以内）和死亡年份（相差2年以内）进行了匹配，并使用条件逻辑回归确定了各种因素对子宫内膜异位症发展的影响。接受三次或更多次雌二醇植入或一次或更多次子宫切开术均为显著的风险因素，估计相对风险分别为9.7（95%置信区间2.5 - 37.2）和5.8（95%置信区间1.6 - 20.2）。接受过一次或更多次腹腔镜检查的动物发生子宫内膜异位症的风险没有增加。这些发现为了解女性该疾病的病因提供了线索。?2P51 4RR00167
