Ascaso F J, Ayala I, Carbonell P, Castro F J, Palomar A
Department of Ophthalmology, University Clinic Hospital, Zaragoza, Spain.
Ophthalmologica. 1997;211(5):292-5. doi: 10.1159/000310811.
During the past decade the demand for outpatient surgery has grown rapidly. Postoperative nausea and vomiting is one of the more common undesirable consequences of surgery, which may significantly delay the patient's discharge from the ambulatory surgery center. None of the currently used antiemetic drugs is considered totally effective in abolishing nausea or vomiting. The purpose of this study was to compare the efficacy of ondansetron, a highly selective 5-hydroxytryptamine subtype-3 receptor antagonist, with that of metoclopramide for the prevention of postoperative emesis in patients undergoing cataract surgery. The incidence of postoperative nausea was significantly less in the ondansetron group than that in the metoclopramide group (p = 0.046). Although the incidence of vomiting was clinically less frequent in the ondansetron group, there were no significant differences between both treatment groups. To our knowledge, this is the first study to demonstrate that ondansetron is effective to prevent postoperative emesis after extracapsular cataract extraction.
在过去十年中，门诊手术的需求迅速增长。术后恶心和呕吐是手术较为常见的不良后果之一，这可能会显著延迟患者从门诊手术中心出院。目前使用的任何一种止吐药物都未被认为能完全有效消除恶心或呕吐。本研究的目的是比较高度选择性5-羟色胺3型受体拮抗剂昂丹司琼与胃复安在预防白内障手术患者术后呕吐方面的疗效。昂丹司琼组术后恶心的发生率显著低于胃复安组（p = 0.046）。虽然昂丹司琼组呕吐的发生率在临床上较低，但两组之间无显著差异。据我们所知，这是第一项证明昂丹司琼对预防白内障囊外摘除术后呕吐有效的研究。
