Pucci M J, Thanassi J A, Discotto L F, Kessler R E, Dougherty T J
Department of Microbiology, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
J Bacteriol. 1997 Sep;179(17):5632-5. doi: 10.1128/jb.179.17.5632-5635.1997.
Clusters of peptidoglycan biosynthesis and cell division genes (DCW genes) were identified and sequenced in two gram-positive cocci, Staphylococcus aureus and Enterococcus faecalis. The results indicated some similarities in organization compared with previously reported bacterial DCW gene clusters, including the presence of penicillin-binding proteins at the left ends and ftsA and ftsZ cell division genes at the right ends of the clusters. However, there were also some important differences, including the absence of several genes, the comparative sizes of the div1B and ftsQ genes, and a wide range of amino acid sequence similarities when the genes of the gram-positive cocci were translated and compared to bacterial homologs.
在两种革兰氏阳性球菌——金黄色葡萄球菌和粪肠球菌中，鉴定并测序了肽聚糖生物合成和细胞分裂基因簇（DCW基因）。结果表明，与先前报道的细菌DCW基因簇相比，它们在组织上存在一些相似之处，包括在簇的左端存在青霉素结合蛋白，在右端存在ftsA和ftsZ细胞分裂基因。然而，也存在一些重要差异，包括几个基因的缺失、div1B和ftsQ基因的相对大小，以及将革兰氏阳性球菌的基因翻译后与细菌同源物进行比较时，氨基酸序列相似性的广泛范围。
