Vijayalakshmi N, Rao R S, Badrinath S
Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Epidemiol Infect. 1997 Aug;119(1):25-8. doi: 10.1017/s0950268897007553.
The antibiotic susceptibility pattern of Vibrio cholerae O139, Bengal, an emerging intestinal pathogen has been determined by the Kirby Bauer technique and the MIC values of some antibiotics against these strains by agar dilution technique. All the strains were susceptible to tetracycline, norfloxacin, ciprofloxacin and a majority was susceptible to gentamicin (95.7%) and nalidixic acid (82.9%). Only 51% were susceptible to cefotaxime and most strains were resistant to furazolidone (95.7%), ampicillin (87.3%) and co-trimoxazole (91.5%). The study shows the importance of judicious use of antibiotics in cholera cases and the need for monitoring the susceptibility status of these strains particularly because of their ability to cause extra-intestinal infections like septicaemia.
通过Kirby Bauer技术确定了新兴肠道病原体霍乱弧菌O139孟加拉型的抗生素敏感性模式，并通过琼脂稀释技术测定了某些抗生素对这些菌株的最低抑菌浓度（MIC）值。所有菌株对四环素、诺氟沙星、环丙沙星敏感，大多数菌株对庆大霉素（95.7%）和萘啶酸（82.9%）敏感。仅51%的菌株对头孢噻肟敏感，大多数菌株对呋喃唑酮（95.7%）、氨苄西林（87.3%）和复方新诺明（91.5%）耐药。该研究表明在霍乱病例中合理使用抗生素的重要性，以及监测这些菌株药敏状态的必要性，特别是因为它们有能力引起败血症等肠外感染。
