Merrill P T, Kim J, Cox T A, Betor C C, McCallum R M, Jaffe G J
Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Curr Eye Res. 1997 Sep;16(9):865-74. doi: 10.1076/ceyr.16.9.865.5048.
Previous epidemiologic studies of uveitis have focused on predominantly Caucasian populations, and none have been based in the Southeast. We analyzed the epidemiology of uveitis among a referral population with a high percentage of African Americans in the United States.
We evaluated demographic data from 385 consecutive patients referred to the Duke Uveitis Clinic.
Of the 385 patients, 120 (31%) were African American and 258 (67%) Caucasian; 237 (62%) were female and 148 (38%) male. The most common diagnoses among the 385 patients were idiopathic panuveitis (64 patients [17%]), idiopathic anterior uveitis (47 patients [12%]), pars planitis (46 patients [12%]), sarcoidosis (44 patients [11%]), and toxoplasmosis (39 patients [10%]). These diagnoses were also the most common among the 120 African American patients: 33 patients (28%) had idiopathic panuveitis, 30 (25%) had sarcoidosis, 10 (8%) had idiopathic anterior uveitis, 8 (7%) had toxoplasmosis, and 6 (5%) had pars planitis. Among the 258 Caucasian patients, the most common diagnoses were pars planitis (39 patients [15%]), idiopathic anterior uveitis (37 patients [14%]), toxoplasmosis (30 patients [12%]), idiopathic panuveitis (28 patients [11%]), and multifocal choroiditis and panuveitis (MCP) (17 patients [7%]). Categorizing diagnoses of all 385 patients by anatomic location, panuveitis was most frequent (148 patients [38%]), followed by anterior uveitis (97 patients [25%]), posterior uveitis (93 patients [24%]), and intermediate uveitis (47 patients [12%]).
The higher frequency of sarcoidosis and idiopathic panuveitis than previously reported is related to our larger African American population base. The racial composition of the Southeast does not, however, account for differences such as our higher percentage of MCP; it is possible that other genetic or environmental factors play a role in this region.
先前关于葡萄膜炎的流行病学研究主要集中在白种人人群，且均未以美国东南部为基础。我们分析了美国一个非裔美国人比例较高的转诊人群中葡萄膜炎的流行病学情况。
我们评估了连续转诊至杜克葡萄膜炎诊所的385例患者的人口统计学数据。
在这385例患者中，120例（31%）为非裔美国人，258例（67%）为白种人；237例（62%）为女性，148例（38%）为男性。385例患者中最常见的诊断为特发性全葡萄膜炎（64例[17%]）、特发性前葡萄膜炎（47例[12%]）、中间葡萄膜炎（46例[12%]）、结节病（44例[11%]）和弓形虫病（39例[10%]）。这些诊断在120例非裔美国患者中也最为常见：33例（28%）患有特发性全葡萄膜炎，30例（25%）患有结节病，10例（8%）患有特发性前葡萄膜炎，8例（7%）患有弓形虫病，6例（5%）患有中间葡萄膜炎。在258例白种人患者中，最常见的诊断为中间葡萄膜炎（39例[15%]）、特发性前葡萄膜炎（37例[14%]）、弓形虫病（30例[12%]）、特发性全葡萄膜炎（28例[11%]）和多灶性脉络膜炎和全葡萄膜炎（MCP）（17例[7%]）。按解剖部位对所有385例患者的诊断进行分类，全葡萄膜炎最为常见（148例[38%]），其次是前葡萄膜炎（97例[25%]）、后葡萄膜炎（93例[24%]）和中间葡萄膜炎（47例[12%]）。
结节病和特发性全葡萄膜炎的发生率高于先前报道，这与我们较大的非裔美国人人口基数有关。然而，东南部的种族构成并不能解释诸如我们较高的MCP发生率等差异；在该地区可能有其他遗传或环境因素起作用。
