Umemura T, Yamashiro S, Bhatnagar M K, Moody D L, Slinger S J
Res Vet Sci. 1977 Sep;23(2):139-45.
Sclerosis of the liver accompanied by hydropericardium of long standing was observed in turkeys fed rapeseed products for 16 weeks. Histologically, extensive increases of fibrous tissue composed predominantly of reticular fibres and centrilobular degeneration of parenchymal cells were the main pathological features. Neither prominent fatty degeneration nor the formation of pseudolobules was observed. The birds fed rapeseed products for four and 12 weeks showed continuing occurrence of multiple focal and/or solitary hepatocytic necroses preceding the process of fibrosis in the livers. Glucosinolates and their hydrolytic products were considered the most likely causative factors for the hepatocytic necrosis.
在喂食油菜籽产品16周的火鸡中观察到伴有长期心包积水的肝硬变。组织学上，主要由网状纤维组成的纤维组织广泛增加以及实质细胞的小叶中心变性是主要病理特征。未观察到明显的脂肪变性或假小叶形成。喂食油菜籽产品4周和12周的禽类在肝脏纤维化过程之前持续出现多处局灶性和/或孤立性肝细胞坏死。硫代葡萄糖苷及其水解产物被认为是肝细胞坏死最可能的致病因素。
