Seiler C A, Renner E L, Schilling M, Reichen J, Büchler M W
Klinik für Viszerale und Transplantationschirurgie, Inselspital, Universität Bern.
Schweiz Med Wochenschr Suppl. 1997;89:31S-35S.
Today, orthotopic liver transplantation (OLT) is the treatment of choice for the endstage of various liver diseases, a 1-year survival rate of 80% and a 5-year survival rate of 70% in elective patients without tumor is reported in international surveys. The liver transplant program of the Inselspital Bern is very small compared with international centers, and this may raise questions about the (long-term) results and the justification for such a program. During the last 63 months, 59 liver transplantations (including two retransplants) have been performed in 57 patients at the Inselspital. The 30-day mortality was 3.5% and the 2.5-year overall survival rate was 82% and 93% for elective cases without tumor. After a median follow-up of 29 months, 67% of all patients were reintegrated fully or part-time in their profession and 81% were independent of others' help. We conclude that even a small liver transplant program based on routine resources only can achieve results which are comparable to international standards.
如今，原位肝移植（OLT）是各种肝脏疾病终末期的首选治疗方法，国际调查显示，择期非肿瘤患者的1年生存率为80%，5年生存率为70%。与国际中心相比，伯尔尼因塞尔医院的肝移植项目规模很小，这可能会让人对（长期）结果以及该项目的合理性产生疑问。在过去的63个月里，因塞尔医院为57名患者进行了59例肝移植手术（包括2例再次移植）。无肿瘤择期病例的30天死亡率为3.5%，2.5年总生存率为82%，93%。经过29个月的中位随访，67%的患者已全职或兼职重新回到工作岗位，81%的患者不再依赖他人帮助。我们得出结论，即使是一个仅基于常规资源的小型肝移植项目，也能取得与国际标准相当的成果。
