Seiler A, Renner E L, Schilling M, Rieder H, Reichen J, Bischoff P, Büchler M W
Klinik für Viszerale und Transplantationschirurgie, Universität Bern, Inselspital.
Chirurg. 1997 Oct;68(10):1004-8; discussion 1009-10. doi: 10.1007/s001040050310.
Today, orthotopic liver transplantation is the treatment of choice for the end-stage of various liver diseases, and a 1-year survival rate of 80% and a 5-year survival rate of 70% in elective patients without tumor are reported in international surveys. The liver transplant programme of the Inselspital in Bern is small compared with international centres, which may raise questions about the results and the justification for such a programme. Over a period of 66 months, 62 liver transplantations were performed in 60 patients at the Inselspital. The hospital mortality was 3.3%, and the 2.5-year overall survival rate was 92% for elective cases without tumor. After a median follow-up of 30 months, 68% of all patients were re-integrated in housework or full- or part-time in their profession, and 83% were independent from the help of others. We conclude that a small liver transplant programme based only on routine resources can achieve results comparable to the international standards.
如今,原位肝移植是各种肝病终末期的首选治疗方法,国际调查显示,非肿瘤择期患者的1年生存率为80%,5年生存率为70%。与国际中心相比,伯尔尼因塞尔医院的肝移植项目规模较小,这可能会让人对该项目的结果及其合理性产生疑问。在66个月的时间里,因塞尔医院为60名患者进行了62例肝移植手术。医院死亡率为3.3%,非肿瘤择期病例的2.5年总生存率为92%。在中位随访30个月后,68%的患者重新从事家务劳动或全职或兼职工作,83%的患者不再需要他人帮助。我们得出结论,仅基于常规资源的小型肝移植项目可以取得与国际标准相当的结果。