Law M P, Osman S, Davenport R J, Cunningham V J, Pike V W, Camici P G
MRC Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Nucl Med Biol. 1997 Jul;24(5):417-24. doi: 10.1016/s0969-8051(97)00007-3.
Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.
在大鼠体内评估了去甲肾上腺素类似物[ N-甲基-11C]间羟基麻黄碱（[11C]mHED）的生物分布和代谢情况。用摄取阻滞剂地昔帕明预处理可降低心肌对放射性的摄取，但对肺、肝、肾和肌肉无此作用。脑摄取可忽略不计。高效液相色谱法显示血浆和肝脏中有六种放射性代谢物，而心肌中没有。将未标记的间羟基麻黄碱或间羟胺与[11C]mHED共同注射，结果表明心肌中，间羟基麻黄碱和间羟胺的体内结合电位无差异。
