Fitzmaurice T, Walker C, Kukreja A, Sun Y, Brown S M, Field H J
Centre for Veterinary Science, Cambridge University Veterinary School, UK.
J Gen Virol. 1997 Sep;78 ( Pt 9):2167-9. doi: 10.1099/0022-1317-78-9-2167.
A series of mutants of equine herpesvirus-1 (EHV-1) which contain deletions in non-essential genes was previously characterized in a murine intranasal infection model. One mutant, ED71 which was shown to be attenuated in the model, was further characterized by inoculation into pregnant mice. Despite the attenuation previously reported, intranasal inoculation of pregnant mice resulted in premature parturition and the birth of dead or dying foetuses. Furthermore, mice inoculated before pregnancy with the same mutant, and subsequently challenged 14 days after conception with wild-type virus, were not protected from abortion.
先前在小鼠鼻内感染模型中对一系列马疱疹病毒1型（EHV-1）突变体进行了表征，这些突变体在非必需基因中存在缺失。其中一个突变体ED71在该模型中显示出减毒特性，通过接种怀孕小鼠对其进行了进一步表征。尽管先前报道了其减毒特性，但对怀孕小鼠进行鼻内接种导致早产以及死胎或濒死胎儿的出生。此外，在怀孕前接种相同突变体的小鼠，在受孕14天后用野生型病毒进行攻击，并未免受流产影响。
