Frödin J E, Ericsson J, Barlow L
Dept of Oncology (Radiumhemmet), Karolinska Hospital, Stockholm, Sweden.
Acta Oncol. 1997;36(5):465-9. doi: 10.3109/02841869709001300.
During the years 1958-1988, 808,522 individuals were registered in the Swedish national population-based cancer register with a total of 933,900 primary malignant tumors. Roughly 11% of the tumors reported to the Swedish Cancer Registry in 1988 were found in persons earlier registered for another primary malignancy. One hundred of the individuals registered with multiple primary malignant tumors were randomly selected for a study of the reliability of reporting of multiple malignancies. Medical records and when necessary histopathological slides and other relevant diagnostic material for each malignancy were collected and the diagnoses reevaluated. Three persons had to be excluded; thus 97 cases with 209 reported malignancies were analysed. Of these, 94% of the first, 98% of the second and 79% of the third malignancy were accepted. Twelve of the reported tumors were not accepted as malignant, five were benign or cancer in situ, five were incorrectly reported as new primaries and two were a second incorrect registration of a previously registered malignancy. All 97 persons had at least one malignant tumor, in 90% of the persons all reported diagnoses were accepted and 93% had multiple primary malignancies. The results of this quality control study indicate that suitable data are available in the Swedish Cancer Registry for investigations related to the occurrence of multiple primary malignancies in a large unselected population. The Swedish Cancer Registry, to which all newly diagnosed malignancies by law have to be reported, comprise today close to one million individuals with registered malignancies.
在1958年至1988年期间，瑞典全国基于人群的癌症登记处登记了808,522人，共有933,900例原发性恶性肿瘤。1988年向瑞典癌症登记处报告的肿瘤中，约11% 是在先前已登记患有另一种原发性恶性肿瘤的人群中发现的。随机选择了100名登记有多种原发性恶性肿瘤的个体，以研究多种恶性肿瘤报告的可靠性。收集了每种恶性肿瘤的病历，并在必要时收集了组织病理学切片和其他相关诊断材料，并对诊断进行了重新评估。有3人必须被排除；因此，对97例报告了209种恶性肿瘤的病例进行了分析。其中，第一种恶性肿瘤的94%、第二种的98% 和第三种的79% 被接受。报告的肿瘤中有12例不被接受为恶性肿瘤，5例为良性或原位癌，5例被错误报告为新的原发性肿瘤，2例是先前登记的恶性肿瘤的第二次错误登记。所有97人都至少有一种恶性肿瘤，90% 的人的所有报告诊断都被接受，93% 的人有多种原发性恶性肿瘤。这项质量控制研究的结果表明，瑞典癌症登记处有合适的数据可用于对大量未经过筛选人群中多种原发性恶性肿瘤的发生情况进行调查。根据法律，所有新诊断的恶性肿瘤都必须向瑞典癌症登记处报告，目前该登记处包含近100万登记有恶性肿瘤的个体。
